To make neinzuls, I'd have ditched all permanent stuctures but one building that would be an extension of the regen chamber.
The "new" regen chamber would have to double as a drone holder of sorts, capable of unleashing hordes on whatever encroaches your territory.
Most of defenses would have to be drones, the fleet of the player the "few" mature units, and the moving enclave.
I'm not sure if it would be better to have the player control multiple flagships, each with its fleet of enclave, rather than enclaves directly.
Leaving a possibility for specialized "leader-less" enclave squads.