I am actually an IT security instructor for a nonprofit that works with blind and visually impaired clients, and I am myself legally blind as well. So, I have a lot of experience working with assorted applications and scenarios where accessibility isn't considered, from remote-assistance tools to UEFI screens. I teach this type of stuff, too, so this falls squarely in my area of expertise.
I can point out a huge amount of problems you will face with AI War 2. Unlike AI War Classic, the galaxy map is not fixed. The zoom level does not allow you to view the galaxy map in its entirety, so some panning will be necessary at some point. Unless you are pixel-precise in your panning, keeping your cursor coordinate bookmarks in line will be tedious at best. Much of the game is based on iconography as well, from the galaxy map to the Planet-view sidebar displaying icons of units. Can you figure out what is on a planet? Yes. Will it be possible to determine specific locations? Doubtful. That becomes important with locations of defenses on AI Planets.
I could continue, but you get my point. I don't doubt that you can find a means of interacting with the game and getting something out of it. But, the amount of working around you'd have to do versus how much you'd get to play the game seems heavily one-sided towards tedious OCR and cursor bookmarking. If that trade-off is worth it for you, then don't let me discourage nor stop you. I just know that, if it were me, I'd likely opt for something else to entertain me.
That said, I have played AI War 2 with my clients as a group in the afternoons after we finish up for the day. I'll have 3-4 students, and 3-4 fleets, describing the landscape and letting them determine what goals they'd like to pursue, who's moving their fleet where, gain XP for their fleets and trade ships, let them discuss who gets the ARS ship line added to their fleet, and so on. It's quite interesting to have 4 of them off doing their own thing, only to bounce around and help each other out, make and set goals, etc., just with me as the one controlling the game given I have enough sight to do so. The hysteria that ensued when we fought the Devourer with 150 strength across 4 fleets and some turrets, me calling out the Devourer's hull every 5% down to zero. I thought they were going to need to change their pants after the parasitic units in our fleet converted the Devourer into a friendly zombie which proceeded to go on a killing spree in AI territory. I've done this with XCOM, Stellaris, FTL, Darkest Dungeon, and many other strategy/tactics style games.
I say all of the above because finding someone to screenshare with and play almost as an over-the-shoulder style co-op might be more enjoyable than fighting with a screen reader for hours on end. As long as the person who's controlling things is good about describing what's going on, and the two of you can discuss and agree on what to do, I think it might be better. I've gotten nothing but positive feedback from my students about our Friday afternoon gaming sessions. Even one of our directors who is blind sometimes comes across the hall to my classroom when we have an hour or two to kill.