The others say there's some imbalances with the other campaign difficulties - I've only tested normal in alpha, and played through on normal. ^^ I play TLF to relax at the moment.
My guess is that after a certain threshold negative RCI makes other bad events more likely to happen, and the situation becomes unfixable. So once Chris/Keith redo the RCI spread it should be somewhat controllable.
= = =
Ah, you do have an andor science outpost - which I thought was manufacturing, and some time ago your science outpost got destroyed. One of my gripes is that the Burlusts *do* have a relapsing Teethworm infection which you can't treat. Although I suppose you can try to give them the vaccine as a free tech.
...which begs the question, how did you get the treatment in the first place? I've tracked the appearance of these events (in your game and my past games) and whenever I go to the planet afterwards the option remains red.