I listened to this podcast. Very nice.
One of those comments made me think you should name the game, The Directive Factor (which is the exact opposite of a prime directive).
Also, I heard you mention that this game has space stations. I have been lobbying for space stations for AI war for quite some time. Please see my planetcracker thread.
As far as the specifics of the game you mentioned, I like everything you said except for the comments about making a shmup minigame. Don't like that idea. Suddenly, an intellectual game becomes twitchy, which is bad.
Things I really liked:
* Being able to view the solar system and see what's going on other planets.
* Having a newsfeed that updates you on the happenings. Actually, this particular part wasn't entirely clear if you were just agreeing with the hosts or if you actually have this implemented. Either way, there needs to be some mechanism of recording the happenings. I would actually like to see all of the news aggregated and saved somewhere as part of my saved game. I like reading stories, and I think I would enjoy reading over the way the game played out. If you don't have a way to see what happened, a lot of the cause-and-effect might be missed, which seems like a central theme to this game.
* Combat sounds fast and exciting, and you mentioned a video coming out. Looking forward to it.
Overall, I enjoyed the interview, and your hosts seemed appropriate to the subject matter. Good job.