In general, I just start getting impatient on Floors 3+, "Caltrops, eh, I can take the damage," and then... I also can't play at anything lower than normal, because that would show I'm inept. And occasionally very frequently I run into some half finished creations, some many of which cannot be killed. So many runs have been ended by the Reanimator.
And then once I get killed, I start thinking I should go work on fixing it rather than actually playing.