I quite like the appearance of things with the interface for the most part, although structure group icons weren't entirely clear in a few instances - Entertainment for one, and the separation between the different types of production buildings for another. I'd say they're a little vague altogether.
When looking at the structure details, those dashed blue divider lines didn't appear to have a real purpose. I expected they'd divide out info groups, but that wasn't the case. They just showed up every two entry lines and cluttered it all up visually.
I wasn't able to find an interface widgit that gave me a per territory breakdown of service production/consumption, and I really, really wanted one.
It was also unclear as to which resources were global and which were territory bound. Worker Populations and Trash, for instance. A lot of that is it being a first playthrough without any instructions though, and you're handling some of these resources differently than most games.
I'm a fan of how you set up the economy with crowns, tying production, construction and combat ordinance together.
The tech tree is set up a bit confusing based on building dependencies and bonuses. Condos get bonuses from mid-level dining which doesn't show up until act 2, but moreso it was the Commercial Offices needing computing power which requires the tech after the one that gets said offices. I can shrug off the bonus thing even if it seems that condos and the mid-level food tech should be roughly parallel, but the service dependency piece seemed very backwards.
Disease modeling is a bit nuts, which is what killed my first game. I had a hospital just in case. I needed at least three more for when an ocular implant parasite showed up because the one hospital couldn't keep up with the spread of the plague. And the disease spread across the ocean and across largish gaps between territories. So it crippled my economy with that lovely 10% efficiency mod hitting every single one of my buildings, which eventually made it so nothing could be built and no one was being cured. I saw a thing about developing a vaccine in the disease info, but it stayed stuck at 0.1% completion. So after burning many turns to see if anything would change, I killed the game as my way of conceding defeat to this holo-entertainment spawned death plague. I'd say that the vaccine thing needs to be fixed or change diseases so that they run their course and go away in time or are simply not able to cripple you entirely so you can get down the hospitals to cure them that way.