Consider the following build:
Century: Wild Garden Age
Health: 45
Attack: 205%
Mana: 50 + 10 upgrades = 261
It sound insane, right? One hit (more or less) and you're dead, but not if you put on a conserving mind enchant and start using shields. With the mana regeneration this character has it should be able to keep a shield up permanently, ignoring its own health completely and use mana instead for defense, and the great thing about mana is that it is limitless and regenerates in a few seconds, something that health does not do.
This build makes most enemies quite easy. Forget about dodging, with a permanent level 5 shield you're a 45 hit point tank, and with enough damage reduction, the shield will not need to be reset as often either. The only problem is that if you make a single mistake while toggling the shield on and off, you're dead. And with the recent enchantment nerf, getting enough damage reduction will be difficult I think.
But if you can live with that, consider windstorms. They drain your health until it reaches 1 point but this build doesn't even care. 1 health or 45 makes no difference when you'll be taking 0 damage.
A wild Environ appeared!
Environ used Windstorm!
It's not very effective...