I have been doing some testing on a new game (60 planets [Simple map], Tank/Entrenched Homeworlder [Moderate], Lvl 6 AI, Teleporting Battlestation start ship, No Astro trains/mines, Complex Ships) and so far the resource boost the new layout gives helps me build my defenses up a bit quicker (especially the power boost). Haven't had a concerted attack against my home system yet (I have yet to poke either of the two MK IV worlds near my home world - working my way through the lower level worlds) and I am sure that I will find my strategy tested through and through when that happens.
I can see now, though, problems when homeworlds just happen to be situated with an Exo-Galaxy Wormhole (like my current epic 20hr+ game) - those allow waves to start right in your home system and require extra defenses there.