I often make frequent reloads, but its almost never because something 'slightly went wrong'. Usually its some great failure on my part (like if i accidentally send my entire strike force through a gate.. with permamines on the other side, ill probably reload)
While playing x3tc (something that was brought up elsewhere that is on my mind), I often will reload of the autopilot decides it prefers pasting me across an asteroid or station, but I will not reload, say, if I take a good deal of hull damage in an encounter (note, I'm talking like capship encounter, not gonna repair laser that..)
As for just an op going incredibly badly, unless it was something i feel is incredibly cheap (see: permamines) then I will just sigh away my disappointment and move on.
For instance for the entire Dyson Campaign in my sig, I did not reload at all during the engagement with the Sphere, although i did have to reload once because I forgot to put my starships in low power before I hit the final AI..
Anyhow, I digress. And need sleep, but thats something else.