For me, ZBombards would be the only one I can think of.
When I'm clearing systems, especially in the early game, my preferred tactic for dealing with them is to individually shift-right-click each bombard with my Raid Starships and let the raids do their thing while my fleet goes around killing guard posts and such.
With their high retreat range and decent speed, nothing else I have can catch them and kill them fast enough.
If I send fleet ships after them, they take forever to die as the fleet ships get in range, fire, stop, then have to move back into range again as the ZBombard has kept retreating the whole time. I find most units in the game has an effective DPS of about 30% due to the ZBombard always running away!
Having said that, I don't think I've ever faced TDLs in the AIs hands.....
D.