In my current singleplayer game (I have a thread open on it), I have a Clusters (Microcosm) map, and I've had the great luck to be in a crosshatch style cluster with two raid engines, hybrid hives, special forces, and gravity drills. This is the first game *I* have ever played where my homeworld had at least four hostile wormholes three hours or so in. It hasn't been so bad, actually. Until I was nearly ready to take out the raid engine, I simply made sure each system I took had four turrets each (of basic, missile, mlrs, laser) along with 4-9 sniper/spider turrets, and one mk1 forcefield, way off of on the edge of the system. My homeworld got the lions share of turrets and forcefields. As long as I went and gathered my entire forces to fight off incoming waves it was fine. It got hairy at one point when the AI started sending waves of armor rotters who just have too much engine health. It was at that point I finally focused on getting my mark two ships to support as well. I did take some extra care maintaining a minimum spare energy level.
There are two ideal places to set up a pair of choke points branching into new clusters. I'm aiming for them now, but given the presence of a broken golem and ARS near each choke, I'll probably duplicate the sniper/spider/logistics satellite system setup to spread out the incoming waves and alert status reinforcements as well as let me situate a full-fledged spire city hub.
I normally prefer the one warp choke setup a *lot*. But given the initial nasty layout, I'm gonna run with and see how far I can take a spread out approach. It'll probably get slaughtered by the exogalactic waves, but if not maybe it'll help with delaying for final challenging ending instead.