I tend to get my back into a nice corner and destroy them to keep them out of my space. On 80 planet maps, this tends to make a very nice difference with no ill effects of bunching for me.
To the original question, mist big structures of odd types are considered "heavy defense," something which bombers, tanks, and certain starships are excellent against (see the startship descriptions, I forget which ones specifically at the moment). With a goodly number of bombers, these things go down extremely quickly.