Ya.
I never even got an attack off.
The 3rd wave of Hybrids attacked at 1:10 game time and got my command station.
On diff seven, with Hybrids enabled on only one AI, first wave of 6 about 0:50, second wave of another 6 at 1:00 and the third wave of 5 more hybrids at 1:10. Note: none of the first wave survived to attack again, but the 3rd wave had some survivors of the 2nd wave in it.
This is me playing total turtle with 2 force fields up, so they destroyed all my turrets before my command station, this was not them rushing past my defences, they took my defences out. I had no resources left at all and I can't see what I would do different to make my defence more powerful either, short of going turrets only and getting no ships at all, but that would leave me no way to expand, ever.
My initial though is to drastically reduce the "Attacker" hybrids health in return for faster speed and a raiding mentality. IE: they dash in, destroy one or two critical structures, dash out. This would make them something that you have to chase down in adjacent systems as a priority but not make them the sledgehammer that they are at the moment. You'd have to make it so they attach to the "Defender" hybrid in that system or something so they just don't always retreat with their faster speed.
No comment on the "Defender" hybrids themselves, I haven't lasted long enough to fight them yet.
D.
edit: Or some sort of cluster penalty for the attacker type hybrids, or something based on AI progress so the attacker type is more dangerous the later in the game it is? But that's connecting it back to the core AI's again.
edit the second:
More seriously, if you're in a situation where they only have to cover 2 chokepoints to seal you in, it's going to get ugly, and it's going to get there quick. We'll be tweaking the severity/rapidity of that down (hybrid spawn rate, etc), but in general that will be true. On a snake map... let's just say you want to write a will before playing hybrids on snake.
In a real game, I would be expanding before they could choke me off, I just played turtle to see just how bad hybrids are in 3.175. On this specific map, it would have been 4 or 5 systems adjacent once I took my first couple.