I recomend this:
Auto AIP 0/0 (I don't like this)
Human Maruaders: Off, 2 or 4
Human Resistance Fighters: 2 or 4
Zenith Miners: 4, 5 or 6. 8 can get annoying.
Zenith Dyson Sphere: 2 or 4
Zenith Devourer: On
Neinzul Rocketry Corps: 10 (yes 10 it's not that bad)
Neinzul Preservation Wardens: Off, 2 or 4
Broken Golems: 4
Botnet Golem: 4
Spirecraft: 4
Schizophrenic: On
Avenger on for both AIs
Astro Trains on for both AIs
Hybrids 4 for both AIs. The other one could have higher than 4 if you want to.
Advanced Hybrid: 4 for the other AI
AIs:
http://www.arcengames.com/mediawiki/index.php?title=AI_War_-_AI_Opponent_TypesSledge Hammer (Herp a derp)
Assassin/Bully (I haven't tried this)
2xSpecial Forces Captain 10/10 (I haven't tried this but the amount of ships flying around the galaxy might cause lot of border aggression)
Spire Hammer (I like this one. It's not the hardest but the Spire Frigates and Destroyers are nasty and powerful)
Raid Engine (Manageable but hard and aggressive)
Techonologist Parasite (Aggressive and nasty)
Technologist Raider (Aggressive and nasty but I find TechParasite to be harder)
Zenith Descendant (Half impossible on 10 diff)
Mad Bomber (Half impossible on 10 diff)
Here's a lobby setup script with the settings mentioned above. I use those settings in most of my games.