I haven't gotten a chance to play the latest beta/RC in multiplayer, because my group plays on Tuesday nights. In whatever version was current then (4.070 or 71, I guess?), though, we didn't run into any desync issues. Not really in any others before that for as long as I can remember, either, other than the usual need to resync when adding/removing a player if they show up late or have to leave early. It's been pretty reliable for us for the past 6-ish months that we've been playing weekly games, since before 4.0. We've been sucking horribly at the game and haven't won even once since 4.0 came out (although a few times we've managed to lose more than once in a single session), but that's a different matter entirely. Heh.