You should search the forums here about that, there is data. From what I recall (and I could be way off, so double check), I believe that VMWare on the Mac runs the game just fine, at normal speed.
To my knowledge the game has never been successfully run on WINE on Linux, though there is a big thread in the tech support forums where some enterprising players did get it to install. Mostly we're just waiting on WINE and Mono to add more support for .NET 3.5 and such.