When playing multiplayer games, no pausing ever, no exceptions. Whatever happens happens. We just deal with it as it comes.
In single player, I pause only in extreme emergencies. I'm sure there have been a handful of other times in the past couple months that I've paused other than the auto-pausing it does during the Fallen Spire campaign, but I can't think of any off the top of my head.
Basically, around here we put the "real-time" in "real-time strategy". Heh.