This isn't a known issue with SlimDX, not that I'm aware of. I would suggest making sure that you have the prerequisite .NET 3.5 installed, and that your .NET 2.0 isn't corrupted (SlimDX is native to .NET 2.0, so if that is corrupted that can sometimes cause issues with SlimDX -- whereas if .NET 2.0 is completely absent, but .NET 3.5 is present, SlimDX has no problems). Hope that helps!