I always play shizo, so I dunno if it holds up against single-type waves, but:
Use mixed, drawn out defences. A small ring of mines around the wormhole, a larger minefield in between the wormhole and your CS, Tractors all along the way, a large concentration of various turrets directly in front of the CS (far enough away to get some extra range, close enough to be repaired by engineers below the FF). Layer your forcefields to gain some extra protection if necessary, be sure to build counter-sniper turrets if the enemy uses snipers. You might also want to combine lightning turrets, flak turrets, and tractor turrets around the wormhole for maximised area damage.
With this, you will string the attackers out all across the system so that the fleet can sweep them away from one end to the other. You can also do this very well throughout multiple systems, although it becomes a little difficult if your territories have branches or exclaves.
And generally speaking, you should always have small garrison details at the ready in all your hubs. Your main fleet will be a little weaker, but the defensive advantage of being able to quickly scramble local response forces is usually worth it.