The wormhole itself isn't terribly problematic, it's the stuff in the rest of the system.
So far, my tactic is simple. Mass everything I've got on my side of the wormhole, including a couple of engineers. Send in a few "Mark I" fighters just to get the enemy lightning turrets/mines/whatever to shoot off. Then, send everything in. Whatever the AI has on the other side doesn't really stand a chance against ~2000 ships jumping in at the same time.
Occasionally, my teammate (who has mobile builders) will put up a force field and some counter sniper turrets.