I'm doing my initial test run and here are the things I've learned:
Distribution nodes are a godsend.
Raptors aren't that bad. Good raiders with a lightning fast speed and cloaking.
Once you kill an AI command station, that +20 AIP makes waves five times as large. I managed to survive that, however.
Logistic/military command stations are your only hope since every planet you take is an uphill battle.
EVERYTHING IS A MARK IV PLANET.
You never have enough to build starships.
Missile Frigates are to be feared. They come in mass quantities, slaughter your fighters, and are immune to warheads.
Fallen spire just isn't worth the trouble.
I don't think I can support the economy to maintain a fleet long enough to not be slaughtered by waves with just one home command station. In my first test run, I was methodically beaten down in an hour by sequential massive missile frigate waves. This is really odd, because I'll have a 600 missile frigate raid, then a 99 bomber raid. I can't help but feel that something's off.