I would say that anyone who likes utter unpredictability in their games should like this one. A penchant for permadeath doesn't hurt.
My favourite gameplay moment ever came from Far Cry 2, playing on Hardcore difficulty with Iron Man (permadeath by honor system) rules. I was happily driving along when I heard an engine rev up behind me. I had a look to see if my pursuer was a car, or a technical with a mounted .30 cal or what — and when I saw that it was a technical with a mounted grenade launcher I swore and veered off the road into the jungle. You haven't known gaming joy until you've careened down a narrow, winding jungle track while a volley of grenades obliterates a stand of saplings just a metre away from you, and catching just one grenade means that you have to hit Delete on your own save file.
After about a kilometre they finally hit a tree, and I doubled back through the jungle on foot to give them some presents from my shotgun. And from that day forward, I walked everywhere in Far Cry 2.
But you see, I don't get that vibe in AVWV
If I am in an ice age region, I see the same ice age enemies. If I go to lava flats I see lava flat enemies.
If I go to a stash, I get the same rewards.
By continent 3 there is not a point where I go "WOW! This is new and unexpected!"
Enchantments get the random vibe somewhat. Because I can look forward to "spinning the luck wheel" and maybe getting a prize. Usually I don't, but I have the potential, and that makes it something to look forward to.