This setup allows the left hand user to coordinate the mouse and the 10 key. Abilities 1-3 are mapped to the mouse, 4-10 to the keypad (I don't see anyone using all of them in the same moment). I recommend using a primary ranged ability as Mouse Left, the miasma whip or fire touch (something to harvest with) as Mouse Right, and a big spell for Mouse 3. Keypad 7 and 9 are nice for utility slots and Keypad 3 and Enter are nice for mashing complimentary spells.
Navigation: Keypad 2, 4, 6, 8
Use: Keypad 5
Jump: Keypad 1
Spell: Keypad 3, 7, 9, Enter, Slash, Star, Dash
Chat: Keypad Plus
KeyBinding:TakeScreenshot|F12|None|None|None|None|None
KeyBinding:MarkAllLocalMessagesAsNew|BackQuote|None|None|None|None|None
KeyBinding:PauseLocalChunk|P|Pause|None|None|None|None
KeyBinding:Debug|F3|None|None|None|None|None
KeyBinding:DebugNetwork|F2|None|None|None|None|None
KeyBinding:DebugCollision|F4|None|None|None|None|None
KeyBinding:DebugGhostInvisible|F5|None|None|None|None|None
KeyBinding:DebugBaseTileLayerInfo|F6|None|None|None|None|None
KeyBinding:DebugCTLTileLayerInfo|F6|None|LeftControl|None|None|None
KeyBinding:DebugEntityAlignmentMode|F7|None|None|None|None|None
KeyBinding:Ingame_Right|Keypad6|None|None|None|None|None
KeyBinding:Ingame_Left|Keypad4|None|None|None|None|None
KeyBinding:Ingame_Up|Keypad8|None|None|None|None|None
KeyBinding:Ingame_Down|Keypad2|None|None|None|None|None
KeyBinding:Ingame_Jump|Keypad1|None|None|None|None|JoystickButton1
KeyBinding:Ingame_ConfirmOrAction2|Keypad5|None|None|None|None|JoystickButton0
KeyBinding:SwitchDirectlyTargetedEntity|Return|None|None|None|None|JoystickButton11
KeyBinding:SwitchActiveAbilityBar|R|None|None|None|None|JoystickButton10
KeyBinding:SwitchActiveAbilityBarReverse|None|None|None|None|None|None
KeyBinding:Ingame_UseAbility1|Alpha1|None|None|None|None|JoystickButton2
KeyBinding:Ingame_UseAbility2|Alpha2|None|None|None|None|JoystickButton3
KeyBinding:Ingame_UseAbility3|Alpha3|None|None|None|None|JoystickButton4
KeyBinding:Ingame_UseAbility4|Alpha4|Keypad7|None|None|None|JoystickButton5
KeyBinding:Ingame_UseAbility5|Alpha5|Keypad9|None|None|None|JoystickButton6
KeyBinding:Ingame_UseAbility6|Alpha6|Keypad3|None|None|None|JoystickButton7
KeyBinding:Ingame_UseAbility7|Alpha7|KeypadEnter|None|None|None|JoystickButton9
KeyBinding:Ingame_UseAbility8|Alpha8|KeypadDivide|None|None|None|None
KeyBinding:Ingame_UseAbility9|KeypadMultiply|None|None|None|None|None
KeyBinding:Ingame_UseAbility0|Alpha0|KeypadMinus|None|None|None|None
KeyBinding:SwitchFirstMouseAbilitySlot|None|None|None|None|None|None
KeyBinding:SwitchFirstMouseAbilitySlotReverse|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility1|None|None|None|None|Mouse0|None
KeyBinding:Ingame_MouseAbility2|None|None|None|None|Mouse1|None
KeyBinding:Ingame_MouseAbility3|None|None|None|None|Mouse2|None
KeyBinding:Ingame_MouseAbility4|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility5|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility6|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility7|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility8|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility9|None|None|None|None|None|None
KeyBinding:Ingame_MouseAbility0|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbility|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus1|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus2|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus3|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus4|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus5|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus6|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus7|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus8|None|None|None|None|None|None
KeyBinding:Ingame_UseHighlightedAbilityPlus9|None|None|None|None|None|None
KeyBinding:OpenMenu_System|Escape|None|None|None|None|JoystickButton8
KeyBinding:OpenChatPopup_UKB2|KeypadPlus|None|None|None|None|None
KeyBinding:OpenChunkMap|Backslash|None|None|None|None|None
KeyBinding:OpenDungeonMap|DownArrow|None|None|None|None|None
KeyBinding:OpenRegionMap|UpArrow|None|None|None|None|None
KeyBinding:Menu_CursorDown|Keypad2|None|None|None|None|None
KeyBinding:Menu_CursorUp|Keypad8|None|None|None|None|None
KeyBinding:Menu_CursorLeft|Keypad4|None|None|None|None|None
KeyBinding:Menu_CursorRight|Keypad6|None|None|None|None|None
KeyBinding:Menu_ConfirmOrAction2|Keypad5|None|None|None|None|JoystickButton0
KeyBinding:Menu_Cancel|Escape|None|None|None|None|JoystickButton1
KeyBinding:Menu_SwitchToNextMainTab|Tab|None|None|None|None|JoystickButton3
KeyBinding:SwitchToGhostMode_UKB1|G|None|LeftControl|None|None|None
KeyBinding:SwitchToNonGhostMode|H|None|None|None|None|None
KeyBinding:TriggerAllPointsOfInterest|O|None|None|None|None|None
KeyBinding:DebugRecreateTestChunk|K|None|LeftControl|None|None|None
KeyBinding:DebugReloadParticlePatterns|F4|None|LeftControl|None|None|None
KeyBinding:DebugShowAllRegions|F3|None|LeftControl|None|None|None
KeyBinding:OpenDebugMenu|L|None|None|None|None|None
KeyBinding:ResetAimingReticle|Q|None|None|None|None|None
KeyBinding:Ingame_DoLookAhead_UKB1|G|None|None|None|None|None
KeyBinding:Ingame_Walk|RightControl|None|None|None|None|None
KeyBinding:OpenInventory_Usable2|Z|None|None|None|None|None
KeyBinding:OpenInventory_Commodities|C|None|None|None|None|None
KeyBinding:OpenReference_Planning|V|None|None|None|None|None
KeyBinding:OpenMenu_Equipment|N|None|None|None|None|None
KeyBinding:Visualizer_ShiftWest_UKB1|LeftArrow|None|LeftControl|None|None|None
KeyBinding:Visualizer_ShiftEast_UKB1|RightArrow|None|LeftControl|None|None|None
KeyBinding:Visualizer_ShiftUp_UKB1|UpArrow|None|LeftControl|None|None|None
KeyBinding:Visualizer_ShiftDown_UKB1|DownArrow|None|LeftControl|None|None|None
KeyBinding:StrategyMap_EnableKeyboardScrolling|LeftShift|None|None|None|None|None
KeyBinding:StrategyMap_AccelerateScrolling|LeftControl|None|None|None|None|None
KeyBinding:SwapLeftAndRightMouseButtons|None|None|None|None|None|None
KeyBinding:SettlementManagement_ToggleBuildList|B|None|None|None|None|None
KeyBinding:SettlementManagement_NextSettlement|None|None|None|None|None|None
KeyBinding:SettlementManagement_PreviousSettlement|None|None|None|None|None|None
KeyBinding:ForceDropQuantityToAll|LeftControl|None|None|None|None|None
KeyBinding:OpenInventory_Enchants2|X|None|None|None|None|None